糖尿病性腎症の進展予防にむけた病期分類-病理-バイオマーカーを統合した診断法の開発

業績

1. Furuichi K, Shimizu M, Yuzawa Y, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hoshino J, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T; Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development. Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis. Clin Exp Nephrol, in press
2. Hara A, Furuichi K, Koshino A, Yasuda H, Tran T, Iwata Y, Sakai N, Shimizu M, Kaneko S, Nakamura H, Wada T. Clinical and Pathological Significance of Autoantibodies to Erythropoietin Receptor in Type 2 Diabetic Patients With Chronic Kidney Disease. Kidney Int Rep, in press
3. Shimizu M, Furuichi K, Toyama T, Funamoto T, Kitajima S, Hara A, Ogawa D, Koya D, Ikeda K, Koshino Y, Kurokawa Y, Abe H, Mori K, Nakayama M, Konishi Y, Samejima KI, Matsui M, Yamauchi H, Gohda T, Fukami K, Nagata D, Yamazaki H, Yuzawa Y, Suzuki Y, Fujimoto S, Maruyama S, Kato S, Naito T, Yoshimura K, Yokoyama H, Wada T; Research Group of Diabetic Nephropathy, the Ministry of Health, Labour, and Welfare of Japan and Japan Agency for Medical Research and Development. Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS. Clin Exp Nephrol, in press
4. Furuichi K, Yuzawa Y, Shimizu M, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T. Nationwide multicentre kidney biopsy study of Japanese patients with type 2 diabetes. Nephrol Dial Transplant, in press
5. Chen PM, Wada T, Chiang CK. Prognostic value of proteinuria and glomerular filtration rate on Taiwanese patients with diabetes mellitus and advanced chronic kidney disease: a single center experience. Clin Exp Nephrol 21(2):307-315, 2017
6. Toyama T, Furuichi K, Shimizu M, Hara A, Iwata Y, Sakai N, Perkovic V, Kobayashi M, Mano T, Kaneko S, Wada T. Relationship between Serum Uric Acid Levels and Chronic Kidney Disease in a Japanese Cohort with Normal or Mildly Reduced Kidney Function. PLoS ONE 10(9):e0137449, 2015
7. Nakade Y, Toyama T, Furuichi K, Kitajima S, Miyajima Y, Fukamachi M, Sagara A, Shinozaki Y, Hara A, Shimizu M, Iwata Y, Oe H, Nagahara M, Horita H, Sakai Y, Kaneko S, Wada T. Impact of kidney function and urinary protein excretion on intima-media thickness in Japanese patients with type 2 diabetes. Clin Exp Nephrol 19(5):909-917, 2015
8. Sakai N, Wada T. T Helper 2 Cytokine Signaling in Bone Marrow-Derived Fibroblasts: A Target for Renal Fibrosis. J Am Soc Nephrol 26(12):2896-2898, 2015
9. Matsui K, Kamijo-Ikemori A, Imai N, Sugaya T, Yasuda T, Tatsunami S, Toyama T, Shimizu M, Furuichi K, Wada T, Shibagaki Y, Kimura K. Clinical significance of urinary liver-type fatty acid-binding protein as a predictor of ESRD and CVD in patients with CKD. Clin Exp Nephrol 20(2):195-203, 2016
10. Araki S, Haneda M, Koya D, Kondo K, Tanaka S, Arima H, Kume S, Nakazawa J, Chin-Kanasaki M, Ugi S, Kawai H, Araki H, Uzu T, Maegawa H. Urinary Potassium Excretion and Renal and Cardiovascular Complications in Patients with Type 2 Diabetes and Normal Renal Function. Clin J Am Soc Nephrol 10(12):2152-2158, 2015
11. Hoshino J, Mise K, Ueno T, Imafuku A, Kawada M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Sawa N, Hara S, Fujii T, Ohashi K, Ubara Y, Takaichi K. A Pathological Scoring System to Predict Renal Out come in Diabetic Nephropathy. Am J Nephrol 41:337-344, 2015
12. Mise K, Hoshino H, Ueno T, Hazue R, Hasegawa J, Sekine A, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Sawa N, Fujii T, Hara S, Ohashi K, Takaichi K, Ubara Y. Prognostic value of tubulointerstitial lesions, urinary N-Acetyl-β-D-Glucosaminidase, and urinary β2-microglobulin in patients with type 2 diabetes and biopsy-proven diabetic nephropathy. Clin J Am Soc Nephrol 11(4):593-601, 2016
13. Shimizu M, Furuichi K, Toyama T, Yamahana J, Ohkawa R, Igarashi K, Aoki J, Kaneko S, Yatomi Y Wada T. Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy. Intern Med 55(3): 215-221, 2016

14. Sato H, Takahashi N, Sato E, Kisu K, Ito S, Saito T. Pathology of glomerular lipidosis. Clin Exp Nephrol, 18: 194-196, 2014

15. Kamijo-Ikemori A, Sugaya T, Kimura K. Novel urinary biomarkers in early diabetic kidney disease. Curr Diab Rep 14, 513, 2014

16. Haneda M, Utsunomiya K, Koya D, Babazono T, Moriya T, Makino H, Kimura K, Suzuki Y, Wada T, Ogawa S , Inaba M, Kanno Y, Shigematsu T, Masakane I, Tsuchiya K, Honda K, Ichikawa K, Shide K. A new classification of Diabetic Nephropathy 2014: a report 3 from Joint Committee on Diabetic Nephropathy. Clin Exp nephrol, 19:1-5, 2015

17. Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes. Clin Exp Nephrol 18:613-620, 2014

18. Sakai N, Wada T. Revisiting inflammation in diabetic nephropathy: the role of the Nlrp3 inflammasome in glomerular resident cells. Kidney Int 87:12-14, 2015

19. 糖尿病性腎症と高血圧性腎硬化症の病理診断への手引き 2014年12月発刊

20. 和田隆志・清水美保・遠山直志・古市賢吾: 糖尿病性腎症：研究と診療の進歩, 日本腎臓学会誌 56:22-27, 2014

21. 日本糖尿病学会：羽田勝計・宇都宮一典・古家大祐・馬場園哲也・守屋達美　日本腎臓学会：槇野博史・木村健二郎・鈴木芳樹・和田隆志・小川晋　日本透析医学会：稲葉雅章・菅野義彦・重松隆・政金生人・土谷健　日本病態栄養学会（オブザーバー）：本田佳子・市川和子・幤憲一郎: 糖尿病性腎症病期分類2014の策定（糖尿病性腎症病期分類改訂）について, 日本腎臓学会誌 56:547-552,2014